Peptide inhibitors of src SH3-SH2-phosphoprotein interactions.
نویسندگان
چکیده
منابع مشابه
Cellular interactions of CRKL, and SH2-SH3 adaptor protein.
Chronic myelogenous leukemia is characterized by a specific chromosomal translocation, t(9;22), in which the ABL protooncogene and the BCR gene become juxtaposed. The chimeric BCR/ABL gene produces a P210 fusion protein with deregulated tyrosine kinase activity. We have recently isolated a complementary DNA, CRKL, which could code for an adaptor protein consisting of one SH2 and two SH3 domains...
متن کاملSh3 Adaptor Protein − Cellular Interactions of Crkl, an Sh2 Updated Version Citing Articles E-mail Alerts Cellular Interactions of Crkl, an Sh2-sh3 Adaptor Protein'
Chronic myelogenous leukemia is characterized by a specific chromo somal translocation, t(9;22), in which the ABL protooncogene and the BCR gene become juxtaposed. The chlmenc BCR/ABL gene produces a P210 fusion protein with deregulated tyrosine kinase activity. We have recently isolated a complementary DNA, CRKL, which could code for an adaptor protein consisting of one SH2 and two SH3 domains...
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SH2 and SH3 domains are small, independent domains of about 100 or 70 amino acid residues respectively. They are found in a variety of proteins, and can occur together or separately. SH2 domains are thought to be involved in signal transduction mechanisms(1). Some SH2 domains control enzyme activity by binding membrane-bound receptors to regulate downstream events such as kinase cascades. Howev...
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The thermodynamics and kinetics of folding of the chicken src SH3 domain were characterized using equilibrium and stopped-flow fluorescence, circular dichroism (CD), and nuclear magnetic resonance (NMR) hydrogen exchange experiments. As found for other SH3 domains, guanidinium chloride (GdmCl) denaturation melts followed by both fluorescence and circular dichroism were nearly superimposable, in...
متن کاملRecent advances in the design and synthesis of SH2 inhibitors of Src, Grb2 and ZAP-70.
A perspective is offered on the recent development of Src-homology 2 (SH2) antagonists of Src, Grb2 and ZAP-70. Inhibiting Src SH2 is believed to be a potentially attractive way of regulating bone resorption. Grb2 SH2 has been shown to be an important component of the mitogenic ras pathway; and thus might be of utility in cancer research. ZAP-70 is a tyrosine kinase that is expressed solely in ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1994
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)31754-x